Does maternal mental well-being in pregnancy impact the early human epigenome?
Identifieur interne : 000E01 ( Main/Exploration ); précédent : 000E00; suivant : 000E02Does maternal mental well-being in pregnancy impact the early human epigenome?
Auteurs : Joanne Ryan [Australie] ; Toby Mansell [Australie] ; Peter Fransquet [Australie] ; Richard Saffery [Australie]Source :
- Epigenomics [ 1750-192X ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- genetics : Pregnancy, Prenatal Exposure Delayed Effects, Stress, Psychological.
- psychology : Pregnancy.
- DNA Methylation, Embryonic Development, Epigenesis, Genetic, Female, Humans, Mental Health.
Abstract
There is considerable interest in the potential nongenetic transmission of a suite of mental health conditions across generations, with epigenetics emerging as a candidate mediator of such effects. This review summarizes findings from 22 studies measuring candidate gene DNA methylation and seven epigenome-wide association studies of offspring epigenetic profile in women with adverse mental wellbeing measures (stress, depression or anxiety) in pregnancy. Despite some compelling evidence to suggest an association, there is a lack of reproducible findings, potentially linked to a number of limitations to this research and the field more broadly. Large cohorts with well characterized exposures across pregnancy are now needed. There is exciting potential that epigenetics may help explain some of the link between maternal wellbeing and child health outcomes, thereby informing novel interventions, but future studies must address current limitations to advance translational knowledge in this area.
DOI: 10.2217/epi-2016-0118
PubMed: 28140666
Affiliations:
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(génétique)</term><term>Grossesse (psychologie)</term><term>Humains</term><term>Méthylation de l'ADN</term><term>Santé mentale</term><term>Stress psychologique (génétique)</term><term>Épigenèse génétique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Grossesse</term><term>Stress psychologique</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Grossesse</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Pregnancy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>DNA Methylation</term><term>Embryonic Development</term><term>Epigenesis, Genetic</term><term>Female</term><term>Humans</term><term>Mental Health</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Développement embryonnaire</term><term>Femelle</term><term>Humains</term><term>Méthylation de l'ADN</term><term>Santé mentale</term><term>Épigenèse génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is considerable interest in the potential nongenetic transmission of a suite of mental health conditions across generations, with epigenetics emerging as a candidate mediator of such effects. This review summarizes findings from 22 studies measuring candidate gene DNA methylation and seven epigenome-wide association studies of offspring epigenetic profile in women with adverse mental wellbeing measures (stress, depression or anxiety) in pregnancy. Despite some compelling evidence to suggest an association, there is a lack of reproducible findings, potentially linked to a number of limitations to this research and the field more broadly. Large cohorts with well characterized exposures across pregnancy are now needed. There is exciting potential that epigenetics may help explain some of the link between maternal wellbeing and child health outcomes, thereby informing novel interventions, but future studies must address current limitations to advance translational knowledge in this area.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Ryan, Joanne" sort="Ryan, Joanne" uniqKey="Ryan J" first="Joanne" last="Ryan">Joanne Ryan</name></region><name sortKey="Fransquet, Peter" sort="Fransquet, Peter" uniqKey="Fransquet P" first="Peter" last="Fransquet">Peter Fransquet</name><name sortKey="Mansell, Toby" sort="Mansell, Toby" uniqKey="Mansell T" first="Toby" last="Mansell">Toby Mansell</name><name sortKey="Saffery, Richard" sort="Saffery, Richard" uniqKey="Saffery R" first="Richard" last="Saffery">Richard Saffery</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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